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KMID : 0363620110320020063
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Journal of Korean Oriental Medicine
2011 Volume.32 No. 2 p.63 ~ p.78
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Protective Effects of Maekmundong-tang on Elastase-induced Lung Injury
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Kim Hyoung-Won
Yang Soo-Young
Kim Min-Hee
Namgoong Uk
Park Yang-Chun
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Abstract
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Objective: This study aimed to evaluate the protective effects of Maekmundong-tang (MMDT) on an elastase-induced COPD model.
Materials and Methods: The extract of MMDT was treated to A549 cells and elastase-induced COPD mice model. Then, various parameters such as cell-based cytoprotective activity and histopathological findings were analyzed.
Results: MMDT showed a protective effect on elastase-induced cytotoxicity in A549 cells. This effect was correlated with analysis for caspase 3 levels, collagen and elastin contents, protein level of Cdk1, and gene expression of TNF- and IL- in A549 cells. MMDT treatment also revealed a protective effect on the elastase-induced COPD mice model. This effect was evidenced via histopathological finding including immunofluorescence stains against elastin, collagen, and caspase 3, and protein level of Cdc2 in lung tissue.
Conclusion: These data suggest that MMDT has pharmaceutical properties on COPD. This study can provide scientific evidence for the efficacy of MMDT for clinical application to patients with COPD.
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KEYWORD
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Maekmundong-tang (Maimendong-tang), chronic obstructive pulmonary disease, A549 cell, elastase
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